The connection between 5-HT7R and inflammation is still limited but is consistently being advanced by the field. 5-HT7R is expressed on the surface of major actors of the peripheral immune response such as T-lymphocytes, macrophages and dendritic cells [40]. The 5-HT7R has recently detected on T regulatory cells infiltrated into the brain after ischaemic stroke [41]. However, 5-HT7R have diverse and even inconsistent roles in the immune response. This is likely due at least to its expression on different types of immune cells, effecting significantly different endpoints. For example, activation of the 5-HT7R can be pro-inflammatory: activation of the 5-HT7R in lymphocytes increases cell proliferation rate [42]. Similarly, in dendritic cells, 5-HT7R activation induces the secretion of proinflammatory cytokines IL-1 and IL-8. By contrast, in monocytes 5-HT7R activation results in either pro- or anti-inflammatory actions [7]. These conundrums can be well addressed by gathering the information and experts to understand the basis for these apparent discrepancies.