{"id":638,"date":"2026-03-07T14:58:38","date_gmt":"2026-03-07T13:58:38","guid":{"rendered":"https:\/\/5-ht7r.org\/?page_id=638"},"modified":"2026-05-04T11:49:56","modified_gmt":"2026-05-04T09:49:56","slug":"models","status":"publish","type":"page","link":"https:\/\/5-ht7r.org\/?page_id=638","title":{"rendered":"Models"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>5-HT7 receptor deficient mouse models:<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Complete list: <a href=\"https:\/\/www.informatics.jax.org\/allele\/summary?markerId=MGI:99841\">https:\/\/www.informatics.jax.org\/allele\/summary?markerId=MGI:99841<\/a> <br>and their availabilities: <a href=\"https:\/\/www.findmice.org\/summary?gaccid=MGI:99841\">https:\/\/www.findmice.org\/summary?gaccid=MGI:99841<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Key publications :<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Mice with complete deletion of 5-HT7<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Witkin JM, Baez M, Yu J, Barton ME, Shannon HE. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy Res. 2007 Jun;75(1):39-45. doi: 10.1016\/j.eplepsyres.2007.03.017<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0920121107001052?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0920121107001052?via%3Dihub<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hedlund PB, Danielson PE, Thomas EA, Slanina K, Carson MJ, Sutcliffe JG. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80. doi: 10.1073\/pnas.0337340100<br><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.0337340100?url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org&amp;rfr_dat=cr_pub++0pubmed\">https:\/\/www.pnas.org\/doi\/10.1073\/pnas.0337340100?url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org&amp;rfr_dat=cr_pub++0pubmed<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44(8):1031-7. doi: 10.1016\/s0028-3908(03)00117-5.<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0028390803001175?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0028390803001175?via%3Dihub<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Rat with complete deletion of 5-HT7<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Demireva EY, Xie H, Flood ED, Thompson JM, Seitz BM, Watts SW. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research. Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152\/physiolgenomics.00030.2019<br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6689730\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6689730<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>BAC-transgenic mouse expressing GFP from 5-HT7 promoter<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Siwiec M, Bobula B, Kielbinski M, Multan N, Hess G, Tokarski K. Activation of 5-HT<sub>7<\/sub> receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse. Pharmacol Rep. 2024 Dec;76(6):1377-1389. doi: 10.1007\/s43440-024-00674-6<br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11582198\/#CR18\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11582198\/#CR18<\/a><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-HT7 receptor deficient mouse models: Complete list: https:\/\/www.informatics.jax.org\/allele\/summary?markerId=MGI:99841 and their availabilities: https:\/\/www.findmice.org\/summary?gaccid=MGI:99841 Key publications : Mice with complete deletion of 5-HT7 Witkin JM, Baez M, Yu J, Barton ME, Shannon HE. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy Res. 2007 Jun;75(1):39-45. doi: 10.1016\/j.eplepsyres.2007.03.017https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0920121107001052?via%3Dihub Hedlund PB, Danielson PE, Thomas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-638","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=638"}],"version-history":[{"count":5,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/638\/revisions"}],"predecessor-version":[{"id":676,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/638\/revisions\/676"}],"wp:attachment":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}