{"id":12,"date":"2026-02-20T18:48:31","date_gmt":"2026-02-20T17:48:31","guid":{"rendered":"https:\/\/5-ht7r.org\/?page_id=12"},"modified":"2026-02-25T17:11:54","modified_gmt":"2026-02-25T16:11:54","slug":"home","status":"publish","type":"page","link":"https:\/\/5-ht7r.org\/","title":{"rendered":"A Website by scientists FOR scientists"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-align-center\">in serotonin research with focus on 5-HT<sub>7<\/sub>, receptor<\/h2>\n\n\n<style>\r\n  @import url('https:\/\/fonts.googleapis.com\/css2?family=Space+Mono:ital,wght@0,400;0,700;1,400&family=Cormorant+Garamond:ital,wght@0,300;0,600;1,300&display=swap');\r\n\r\n  *, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }\r\n\r\n  \/*body {\r\n    background: #111;\r\n    display: flex;\r\n    align-items: center;\r\n    justify-content: center;\r\n    min-height: 100vh;\r\n    font-family: 'Space Mono', monospace;\r\n  }*\/\r\n\r\n  \/* \u2500\u2500 THE CONTAINER 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class=\"noise\"><\/div>\r\n\r\n  <!-- Scan line -->\r\n  <div class=\"scanline\"><\/div>\r\n\r\n  <!-- Corners -->\r\n  <div class=\"corner tl\"><svg viewbox=\"0 0 52 52\" fill=\"none\" stroke=\"#1a7fff\" stroke-width=\"1.4\"><path d=\"M0 52 L0 0 L52 0\"\/><path d=\"M8 52 L8 8 L52 8\" opacity=\"0.38\"\/><\/svg><\/div>\r\n  <div class=\"corner tr\"><svg viewbox=\"0 0 52 52\" fill=\"none\" stroke=\"#1a7fff\" stroke-width=\"1.4\"><path d=\"M0 52 L0 0 L52 0\"\/><path d=\"M8 52 L8 8 L52 8\" opacity=\"0.38\"\/><\/svg><\/div>\r\n  <div class=\"corner bl\"><svg viewbox=\"0 0 52 52\" fill=\"none\" stroke=\"#1a7fff\" stroke-width=\"1.4\"><path d=\"M0 52 L0 0 L52 0\"\/><path d=\"M8 52 L8 8 L52 8\" opacity=\"0.38\"\/><\/svg><\/div>\r\n  <div class=\"corner br\"><svg viewbox=\"0 0 52 52\" fill=\"none\" stroke=\"#1a7fff\" stroke-width=\"1.4\"><path d=\"M0 52 L0 0 L52 0\"\/><path d=\"M8 52 L8 8 L52 8\" opacity=\"0.38\"\/><\/svg><\/div>\r\n\r\n  <!-- Title -->\r\n  <div class=\"title-block\">\r\n    <h1>Receptors <span>5-HT<sub>7<\/sub><\/span><\/h1>\r\n    <div class=\"subtitle\">Serotonine \u00b7 Pharmacology \u00b7 Neurosciences<\/div>\r\n  <\/div>\r\n\r\n  <!-- Outer molecular ring (7 TM domains) -->\r\n  <div class=\"molecule-center\">\r\n    <svg viewbox=\"0 0 280 280\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n      <circle cx=\"140\" cy=\"140\" r=\"128\" stroke=\"#1a7fff\" stroke-width=\"0.7\" stroke-dasharray=\"4 6\" opacity=\"0.45\"\/>\r\n      <circle cx=\"140\" cy=\"140\" r=\"115\" stroke=\"#0044cc\" stroke-width=\"0.5\" stroke-dasharray=\"2 9\"  opacity=\"0.35\"\/>\r\n      <!-- Heptagonal TM arrangement -->\r\n      <g opacity=\"0.72\" stroke=\"#1a7fff\" stroke-width=\"1.1\">\r\n        <circle cx=\"140\" cy=\"12\"  r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"252\" cy=\"76\"  r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"252\" cy=\"204\" r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"140\" cy=\"268\" r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"28\"  cy=\"204\" r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"28\"  cy=\"76\"  r=\"5\" fill=\"#1a7fff\" opacity=\"0.85\"\/>\r\n        <circle cx=\"196\" cy=\"34\"  r=\"4\" fill=\"#60b8f0\" opacity=\"0.7\"\/>\r\n        <line x1=\"140\" y1=\"12\"  x2=\"252\" y2=\"76\"\/>\r\n        <line x1=\"252\" y1=\"76\"  x2=\"252\" y2=\"204\"\/>\r\n        <line x1=\"252\" y1=\"204\" x2=\"140\" y2=\"268\"\/>\r\n        <line x1=\"140\" y1=\"268\" x2=\"28\"  y2=\"204\"\/>\r\n        <line x1=\"28\"  y1=\"204\" x2=\"28\"  y2=\"76\"\/>\r\n        <line x1=\"28\"  y1=\"76\"  x2=\"140\" y2=\"12\"\/>\r\n      <\/g>\r\n      <!-- mid-ring accent nodes -->\r\n      <g opacity=\"0.45\" stroke=\"#60b8f0\" stroke-width=\"0.7\">\r\n        <circle cx=\"140\" cy=\"45\"  r=\"2.5\" fill=\"#60b8f0\"\/>\r\n        <circle cx=\"220\" cy=\"93\"  r=\"2.5\" fill=\"#60b8f0\"\/>\r\n        <circle cx=\"220\" cy=\"187\" r=\"2.5\" fill=\"#60b8f0\"\/>\r\n        <circle cx=\"140\" cy=\"235\" r=\"2.5\" fill=\"#60b8f0\"\/>\r\n        <circle cx=\"60\"  cy=\"187\" r=\"2.5\" fill=\"#60b8f0\"\/>\r\n        <circle cx=\"60\"  cy=\"93\"  r=\"2.5\" fill=\"#60b8f0\"\/>\r\n      <\/g>\r\n      <!-- TM labels -->\r\n      <g font-family=\"Space Mono\" font-size=\"7\" fill=\"#1a7fff\" opacity=\"0.65\">\r\n        <text x=\"125\" y=\"9\">TM1<\/text>\r\n        <text x=\"254\" y=\"74\">TM2<\/text>\r\n        <text x=\"254\" y=\"208\">TM3<\/text>\r\n        <text x=\"125\" y=\"278\">TM4<\/text>\r\n        <text x=\"8\"   y=\"208\">TM5<\/text>\r\n        <text x=\"8\"   y=\"74\">TM6<\/text>\r\n      <\/g>\r\n      <text x=\"115\" y=\"165\" font-family=\"Space Mono\" font-size=\"7\" fill=\"#60b8f0\" opacity=\"0.55\">TM7<\/text>\r\n      <text x=\"90\"  y=\"180\" font-family=\"Space Mono\" font-size=\"6\" fill=\"#7b44ee\" opacity=\"0.65\">Gs \u00b7 cAMP\u2191<\/text>\r\n    <\/svg>\r\n  <\/div>\r\n\r\n  <!-- Inner indole \/ serotonin ring -->\r\n  <div class=\"inner-ring\">\r\n    <svg viewbox=\"0 0 148 148\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n      <circle cx=\"74\" cy=\"74\" r=\"62\" stroke=\"#7b44ee\" stroke-width=\"0.8\" stroke-dasharray=\"3 5\" opacity=\"0.5\"\/>\r\n      <g stroke=\"#7b44ee\" stroke-width=\"1.4\" opacity=\"0.88\">\r\n        <polygon points=\"74,22 98,38 98,68 74,84 50,68 50,38\" fill=\"none\"\/>\r\n        <polygon points=\"74,84 90,100 83,120 65,120 58,100\" fill=\"none\"\/>\r\n        <line x1=\"74\" y1=\"84\" x2=\"74\" y2=\"22\" opacity=\"0.25\"\/>\r\n      <\/g>\r\n      <g font-family=\"Space Mono\" font-size=\"6\" fill=\"#7b44ee\" opacity=\"0.9\">\r\n        <text x=\"68\" y=\"18\">C2<\/text>\r\n        <text x=\"100\" y=\"38\">C3<\/text>\r\n        <text x=\"100\" y=\"70\">C4<\/text>\r\n        <text x=\"68\" y=\"92\">N<\/text>\r\n        <text x=\"38\" y=\"70\">C5<\/text>\r\n        <text x=\"38\" y=\"38\">C6<\/text>\r\n      <\/g>\r\n      <g stroke=\"#0044cc\" stroke-width=\"0.9\" opacity=\"0.7\">\r\n        <line x1=\"74\" y1=\"22\" x2=\"74\" y2=\"8\"\/>\r\n        <circle cx=\"74\" cy=\"6\" r=\"3.5\" fill=\"#0044cc\" opacity=\"0.6\"\/>\r\n        <text x=\"66\" y=\"5\" font-family=\"Space Mono\" font-size=\"5\" fill=\"#0044cc\">OH<\/text>\r\n      <\/g>\r\n      <g stroke=\"#0044cc\" stroke-width=\"0.9\" opacity=\"0.65\">\r\n        <line x1=\"83\" y1=\"120\" x2=\"83\" y2=\"134\"\/>\r\n        <text x=\"71\" y=\"143\" font-family=\"Space Mono\" font-size=\"6\" fill=\"#0044cc\">NH\u2082<\/text>\r\n      <\/g>\r\n    <\/svg>\r\n  <\/div>\r\n\r\n  <!-- Center label -->\r\n  <div class=\"center-label\">\r\n    <div class=\"receptor-name\">5-HT\u2087<\/div>\r\n    <div class=\"receptor-sub\"><span class='tooltipsall tooltipsincontent classtoolTips5'>GPCR<\/span> \u00b7 Classe A<\/div>\r\n  <\/div>\r\n\r\n  <!-- Panels -->\r\n  <div class=\"panel panel-tl\">\r\n    <h3>Research Areas<\/h3>\r\n    <ul>\r\n      <li>Neurosciences<\/li>\r\n      <li>Cardiovascular system<\/li>\r\n      <li>Gastrointestinal tract<\/li>\r\n      <li>Immune system<\/li>\r\n      <!-- <li>Douleur neuropathique<\/li>\r\n      <li>Schizophr\u00e9nie<\/li>\r\n      <li>Syndrome de Rett<\/li> -->\r\n    <\/ul>\r\n  <\/div>\r\n\r\n  <div class=\"panel panel-tr\">\r\n    <h3>Keys of Pharmacology<\/h3>\r\n    <ul>\r\n      <li>Agonists<\/li>\r\n      <li>Antagonists<\/li>\r\n      <li>Biased ligands<\/li>\r\n\t  <li>Labelled ligands<\/li>\r\n\t  <!-- <li>Antipsychotiques : Clozapine<\/li>\r\n      <li>Antid\u00e9presseurs : Vortiox\u00e9tine<\/li>\r\n      <li>Voie : Gs \u2192 AC \u2192 AMPc\u2191<\/li>\r\n      <li>Isoformes : 5-HT7a\/b\/c\/d<\/li> -->\r\n    <\/ul>\r\n  <\/div>\r\n\r\n  <div class=\"panel panel-bl\">\r\n    <h3>Signaling pathways<\/h3>\r\n    \r\n\t<div class=\"bar\" style=\"width:90%;background:linear-gradient(90deg,#1a7fff,transparent)\"><\/div>\r\n\t<p>canonical pathways<\/p>\r\n\t<p>non canonical pathways<\/p>\r\n\t  \r\n    <!-- <p>Gs \/ AMPc \u00a0\u2588\u2588\u2588\u2588\u2588\u2588\u2588\u2588 90%<\/p>\r\n    <div class=\"bar\" style=\"width:55%;background:linear-gradient(90deg,#60b8f0,transparent)\"><\/div>\r\n    <p>\u03b2-arrestine \u00a0\u2588\u2588\u2588\u2588 55%<\/p>\r\n    <div class=\"bar\" style=\"width:40%;background:linear-gradient(90deg,#7b44ee,transparent)\"><\/div>\r\n    <p>ERK1\/2 MAPK \u2588\u2588\u2588 40%<\/p>\r\n    <div class=\"bar\" style=\"width:28%;background:linear-gradient(90deg,#0044cc,transparent)\"><\/div>\r\n    <p>mTOR \/ Src \u00a0\u2588\u2588 28%<\/p> -->\r\n  <\/div>\r\n\r\n  <div class=\"panel panel-br\">\r\n    <h3>Regions of the brain<\/h3>\r\n    <div>\r\n      <span class=\"tag\">Tissue<\/span>\r\n      <span class=\"tag\">Blodd<\/span>\r\n      <span class=\"tag\">Cell line<\/span>\r\n      <!-- <span class=\"tag\">Cortex frontal<\/span>\r\n      <span class=\"tag\">Amygdale<\/span>\r\n      <span class=\"tag\">Striatum<\/span>\r\n      <span class=\"tag\">Raph\u00e9 dorsal<\/span>\r\n      <span class=\"tag\">Cellules gliales<\/span> -->\r\n    <\/div>\r\n  <\/div>\r\n\r\n  <!-- Signal labels -->\r\n  <!-- <div class=\"signal-label sl1\">cAMP \u00b7 PKA \u00b7 CREB \u00b7 Expression g\u00e9nique<\/div>\r\n  <div class=\"signal-label sl2\">Neuromodulation S\u00e9rotoninergique<\/div>\r\n  <div class=\"signal-label sl3\">Plasticit\u00e9 Synaptique \u00b7 LTP \u00b7 LTD<\/div> -->\r\n\r\n<\/div><!-- \/#banner -->\r\n\r\n\n\n<script type='text\/javascript'>\nvar id = \"276\";<\/script>\n<script type='text\/javascript' src='https:\/\/5-ht7r.org\/wp-content\/uploads\/winp-css-js\/276.js?ver=1771755870'><\/script>\n\n\n\n<p class=\"has-text-align-center has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-ffbb763e2902ac90959f04d19849e7f9\">Acronym: i-5HT7net (international network on 5-HT 7 R)<\/p>\n\n\n\n<p><\/p>\n<script type=\"text\/javascript\"> toolTips('.classtoolTips5','<b>G protein-coupled receptors<\/b>'); <\/script>","protected":false},"excerpt":{"rendered":"<p>in serotonin research with focus on 5-HT7, receptor Acronym: i-5HT7net (international network on 5-HT 7 R)<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12"}],"version-history":[{"count":13,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":628,"href":"https:\/\/5-ht7r.org\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions\/628"}],"wp:attachment":[{"href":"https:\/\/5-ht7r.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}