5-HT7 receptor deficient mouse models:
Complete list: https://www.informatics.jax.org/allele/summary?markerId=MGI:99841
and their availabilities: https://www.findmice.org/summary?gaccid=MGI:99841
Key publications :
Mice with complete deletion of 5-HT7
Witkin JM, Baez M, Yu J, Barton ME, Shannon HE. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy Res. 2007 Jun;75(1):39-45. doi: 10.1016/j.eplepsyres.2007.03.017
https://www.sciencedirect.com/science/article/pii/S0920121107001052?via%3Dihub
Hedlund PB, Danielson PE, Thomas EA, Slanina K, Carson MJ, Sutcliffe JG. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80. doi: 10.1073/pnas.0337340100
https://www.pnas.org/doi/10.1073/pnas.0337340100?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44(8):1031-7. doi: 10.1016/s0028-3908(03)00117-5.
https://www.sciencedirect.com/science/article/pii/S0028390803001175?via%3Dihub
Rat with complete deletion of 5-HT7
Demireva EY, Xie H, Flood ED, Thompson JM, Seitz BM, Watts SW. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research. Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019
https://pmc.ncbi.nlm.nih.gov/articles/PMC6689730
BAC-transgenic mouse expressing GFP from 5-HT7 promoter
Siwiec M, Bobula B, Kielbinski M, Multan N, Hess G, Tokarski K. Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse. Pharmacol Rep. 2024 Dec;76(6):1377-1389. doi: 10.1007/s43440-024-00674-6
https://pmc.ncbi.nlm.nih.gov/articles/PMC11582198/#CR18